Version 5.4
Mus musculus Gene: Slc6a11
Summary
InnateDB Gene IDBG-178737.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc6a11
Gene Name solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000030307
Encoded Proteins
IDBP-178739
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132164:
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABAergic neurotransmission is terminated by the uptake of GABA into the presynaptic terminal and the surrounding astroglial cells by sodium-dependent transporters, such as SLC6A11 (Borden et al., 1994 [PubMed 7874447]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:114131241-114249886
Strand Forward strand
Band E3
Transcripts
ENSMUST00000032451 ENSMUSP00000032451
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004014 adenosylmethionine decarboxylase activity
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005332 gamma-aminobutyric acid:sodium symporter activity
GO:0042165 neurotransmitter binding
Biological Process
GO:0006836 neurotransmitter transport
GO:0007420 brain development
GO:0008295 spermidine biosynthetic process
GO:0015812 gamma-aminobutyric acid transport
GO:0042493 response to drug
GO:0055085 transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132164
View Gene Order
ENSBTAG00000038962
Not yet available
Pathways
NETPATH
REACTOME
REACT_217615
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_245631
GABA synthesis, release, reuptake and degradation pathway
REACT_253228
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_247910
Reuptake of GABA pathway
REACT_250087
Neurotransmitter Release Cycle pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_259290
Neuronal System pathway
REACT_233318
Transmission across Chemical Synapses pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20506
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_813
Creatine metabolism pathway
REACT_23910
Reuptake of GABA pathway
REACT_23947
GABA synthesis, release, reuptake and degradation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.44683
RefSeq NM_172890
OMIM
CCDS CCDS39597
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca