InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pf4

Summary

InnateDB Protein

IDBP-178818.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pf4

Protein Name

platelet factor 4

Synonyms

Cxcl4; Scyb4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031320

InnateDB Gene

IDBG-178816 (Pf4)

Protein Structure

UniProt Annotation

Function

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0048248	CXCR3 chemokine receptor binding

Biological Process

GO:0006461	protein complex assembly
GO:0006955	immune response
GO:0016525	negative regulation of angiogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0030168	platelet activation
GO:0030595	leukocyte chemotaxis
GO:0030816	positive regulation of cAMP metabolic process
GO:0042127	regulation of cell proliferation
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045653	negative regulation of megakaryocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter