InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aes

Summary

InnateDB Protein

IDBP-178826.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aes

Protein Name

amino-terminal enhancer of split

Synonyms

AL024115; Esp1; Grg; Grg-5; Grg5; Tle5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002518

InnateDB Gene

IDBG-178824 (Aes)

Protein Structure

UniProt Annotation

Function

Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. {ECO:0000269PubMed:12050133}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12050133}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in developing embryos by midgestation, a wide expression is conserved in adult. In mouse, abundantly expressed in muscle, heart and brain. {ECO:0000269PubMed:8369224}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0010629	negative regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0031668	cellular response to extracellular stimulus
GO:0032091	negative regulation of protein binding
GO:0040008	regulation of growth
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060761	negative regulation of response to cytokine stimulus
GO:0070555	response to interleukin-1
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000210	positive regulation of anoikis