Version 5.4
Mus musculus Gene: Aes
Summary
InnateDB Gene IDBG-178824.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aes
Gene Name amino-terminal enhancer of split
Synonyms AL024115; Esp1; Grg; Grg-5; Grg5; Tle5
Species Mus musculus
Ensembl Gene ENSMUSG00000054452
Encoded Proteins
IDBP-178826
amino-terminal enhancer of split
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to the Aes (amino-terminal enhancer of split) subgroup of the Groucho/transducin-like Enhancer of split (TLE) family of proteins that function as transcriptional corepressors. The encoded protein plays a role in neurological development and cell-fate determination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81559494-81566362
Strand Forward strand
Band C1
Transcripts
ENSMUST00000002518 ENSMUSP00000002518
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010629 negative regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0031668 cellular response to extracellular stimulus
GO:0032091 negative regulation of protein binding
GO:0040008 regulation of growth
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070555 response to interleukin-1
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000210 positive regulation of anoikis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104964
View Gene Order
ENSBTAG00000031363
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_258066
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_203336
Degradation of beta-catenin by the destruction complex pathway
REACT_233471
repression of WNT target genes pathway
REACT_235529
AMER1 mutants destabilize the destruction complex pathway
REACT_231507
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_258576
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_230286
APC truncation mutants have impaired AXIN binding pathway
REACT_241514
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_236203
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_234076
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_252458
AXIN missense mutants destabilize the destruction complex pathway
REACT_263691
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_248000
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_261276
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_254498
TCF7L2 mutants don't bind CTBP pathway
REACT_250714
truncations of AMER1 destabilize the destruction complex pathway
REACT_188257
Signal Transduction pathway
REACT_237096
truncated APC mutants destabilize the destruction complex pathway
REACT_260752
S33 mutants of beta-catenin aren't phosphorylated pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_228106
repression of WNT target genes pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt P63002
TrEMBL B7ZNK7 Q3TYD9
UniProt Splice Variant
Entrez Gene 14797
UniGene
RefSeq NM_001276288 NM_010347
OMIM
CCDS CCDS24062
HPRD
IMGT
MGI ID MGI:95806
MGI Symbol Aes
EMBL AK131845 AK158714 BC132217 BC132219 BC145299 CH466553 L12140 X73359 X73361
GenPept AAA03023 AAI32218 AAI32220 AAI45300 BAE20827 BAE34624 CAA51769 CAA51771 EDL31398 EDL31399
RNA Seq Atlas 14797

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca