Version 5.4
Mus musculus Protein: Cxcl3
Summary
InnateDB Protein IDBP-178848.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cxcl3
Protein Name chemokine (C-X-C motif) ligand 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000031326
InnateDB Gene IDBG-178846 (Cxcl3)
Protein Structure
UniProt Annotation
Function Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. {ECO:0000250UniProtKB:Q10746, ECO:0000269PubMed:14764687}.
Subcellular Localization Secreted {ECO:0000250UniProtKB:Q10746}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008009 chemokine activity
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0030593 neutrophil chemotaxis
GO:0032496 response to lipopolysaccharide
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:3037818
InterPro IPR001089 CXC chemokine
IPR001811 Chemokine interleukin-8-like domain
PFAM PF00048
PRINTS PR00437
PIRSF
SMART SM00199
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6W5C0
PhosphoSite PhosphoSite-Q6W5C0
TrEMBL
UniProt Splice Variant
Entrez Gene 330122
UniGene Mm.471352
RefSeq NP_976065
MGI ID
MGI Symbol Cxcl3
OMIM
CCDS CCDS19417
HPRD
IMGT
EMBL AK144158 AK150314 AK154334 AY311403 AY311404 BC117014 BC117016 CH466617
GenPept AAI17015 AAI17017 AAQ86936 AAQ86937 BAE25738 BAE29460 BAE32520 EDL05303

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca