InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddr1

Summary

InnateDB Protein

IDBP-178875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddr1

Protein Name

discoidin domain receptor family, member 1

Synonyms

6030432F18; AI323681; Cak; CD167a; Nep; PTK3A;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003628

InnateDB Gene

IDBG-178873 (Ddr1)

Protein Structure

UniProt Annotation

Function

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. {ECO:0000250, ECO:0000269PubMed:12065315}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Detected in the cochlea and the organ of Corti in the inner ear. Isoform 1 is predominant and is expressed in developing embryo and adult brain. Isoform 2 is expressed in various epithelial cells. {ECO:0000269PubMed:18026164}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005518	collagen binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0038062	protein tyrosine kinase collagen receptor activity
GO:0046872	metal ion binding

Biological Process

GO:0001558	regulation of cell growth
GO:0001952	regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007566	embryo implantation
GO:0007595	lactation
GO:0008285	negative regulation of cell proliferation
GO:0010715	regulation of extracellular matrix disassembly
GO:0014909	smooth muscle cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
GO:0038083	peptidyl-tyrosine autophosphorylation
GO:0043583	ear development
GO:0044319	wound healing, spreading of cells
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060749	mammary gland alveolus development
GO:0061302	smooth muscle cell-matrix adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:99216

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR008979 Galactose-binding domain-like
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00754
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00231
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt