InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nkd1

Summary

InnateDB Protein

IDBP-178951.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nkd1

Protein Name

naked cuticle 1 homolog (Drosophila)

Synonyms

2810434J10Rik; 9030215G15Rik; Nkd;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034086

InnateDB Gene

IDBG-178949 (Nkd1)

Protein Structure

UniProt Annotation

Function

Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for spermatogenesis. {ECO:0000269PubMed:11274398, ECO:0000269PubMed:11356022, ECO:0000269PubMed:15546883}.

Subcellular Localization

Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in lung. Also expressed in brain, heart, kidney, liver, skin, stomach and testis. Within the testis expression is found in the seminiferous epithelium and round and elongating spermatids. {ECO:0000269PubMed:11274398, ECO:0000269PubMed:11356022, ECO:0000269PubMed:15546883}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030165	PDZ domain binding

Biological Process

GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0016055	Wnt signaling pathway
GO:0030154	cell differentiation
GO:0030178	negative regulation of Wnt signaling pathway
GO:0045732	positive regulation of protein catabolic process
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1901231	positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade
GO:1901233	negative regulation of convergent extension involved in axis elongation
GO:2000096	positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway