Version 5.4
Mus musculus Gene: Nkd1
Summary
InnateDB Gene IDBG-178949.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nkd1
Gene Name naked cuticle 1 homolog (Drosophila)
Synonyms 2810434J10Rik; 9030215G15Rik; Nkd
Species Mus musculus
Ensembl Gene ENSMUSG00000031661
Encoded Proteins
IDBP-178951
naked cuticle 1 homolog (Drosophila)
IDBP-621344
naked cuticle 1 homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140807:
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:88521344-88594887
Strand Forward strand
Band C3
Transcripts
ENSMUST00000034086 ENSMUSP00000034086
ENSMUST00000169179 ENSMUSP00000125935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030165 PDZ domain binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0016055 Wnt signaling pathway
GO:0030154 cell differentiation
GO:0030178 negative regulation of Wnt signaling pathway
GO:0045732 positive regulation of protein catabolic process
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1901231 positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade
GO:1901233 negative regulation of convergent extension involved in axis elongation
GO:2000096 positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140807
View Gene Order
ENSBTAG00000012295
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04310
Wnt signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.30219 Mm.472081
RefSeq NM_001163660 NM_027280
OMIM
CCDS CCDS22511 CCDS52631
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca