InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nudt18

Summary

InnateDB Protein

IDBP-179074.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nudt18

Protein Name

nudix (nucleoside diphosphate linked moiety X)-type motif 18

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086450

InnateDB Gene

IDBG-179072 (Nudt18)

Protein Structure

UniProt Annotation

Function

Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8- oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8- oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0044715	8-oxo-dGDP phosphatase activity
GO:0044716	8-oxo-GDP phosphatase activity
GO:0044717	8-hydroxy-dADP phosphatase activity