InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Flot1

Summary

InnateDB Protein

IDBP-179085.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Flot1

Protein Name

flotillin 1

Synonyms

reggie-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001569

InnateDB Gene

IDBG-179083 (Flot1)

Protein Structure

UniProt Annotation

Function

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

Subcellular Localization

Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Melanosome {ECO:0000250}. Endosome {ECO:0000250}. Note=Membrane-associated protein of caveolae.

Disease Associations

Tissue Specificity

High expression in brain, white adipose tissue, heart muscle, skeletal muscle and lung. Low expression in spleen, liver and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	73 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0035255	ionotropic glutamate receptor binding

Biological Process

GO:0007409	axonogenesis
GO:0022617	extracellular matrix disassembly
GO:0035023	regulation of Rho protein signal transduction
GO:0072659	protein localization to plasma membrane
GO:0090002	establishment of protein localization to plasma membrane

Cellular Component

GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005815	microtubule organizing center
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0008180	COP9 signalosome
GO:0016020	membrane
GO:0016600	flotillin complex
GO:0034451	centriolar satellite
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome