InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Flot1

Summary

InnateDB Gene

IDBG-179083.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Flot1

Gene Name

flotillin 1

Synonyms

reggie-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059714

Encoded Proteins

IDBP-179085

flotillin 1

IDBP-628280

flotillin 1

IDBP-628281

flotillin 1

IDBP-628282

flotillin 1

IDBP-628283

flotillin 1

IDBP-628284

flotillin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137312:
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined. [provided by RefSeq, Jul 2008]
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:35823230-35832791

Strand

Forward strand

Band

Transcripts

ENSMUST00000001569	ENSMUSP00000001569
ENSMUST00000174080	ENSMUSP00000134227
ENSMUST00000173628	ENSMUSP00000133289
ENSMUST00000174227
ENSMUST00000173493	ENSMUSP00000134699
ENSMUST00000173147	ENSMUSP00000133454
ENSMUST00000172846	ENSMUSP00000134681
ENSMUST00000173337
ENSMUST00000173381
ENSMUST00000173273
ENSMUST00000174297

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	73 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0035255	ionotropic glutamate receptor binding

Biological Process

GO:0007409	axonogenesis
GO:0022617	extracellular matrix disassembly
GO:0035023	regulation of Rho protein signal transduction
GO:0072659	protein localization to plasma membrane
GO:0090002	establishment of protein localization to plasma membrane

Cellular Component

GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005815	microtubule organizing center
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0008180	COP9 signalosome
GO:0016020	membrane
GO:0016600	flotillin complex
GO:0034451	centriolar satellite
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000137312

View Gene Order

ENSBTAG00000009960

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04910

Insulin signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

hsa04910

Insulin signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

O08917

TrEMBL

G3UWW8 G3UYU4 G3UZZ5 G3XA73 Q540I4 Q6Y9S2

UniProt Splice Variant

Entrez Gene

14251

UniGene

Mm.2931

RefSeq

NM_008027 XM_006523656 XM_006536516 XM_006537249

OMIM

CCDS

CCDS28705

HPRD

IMGT

MGI ID

MGI:1100500

MGI Symbol

Flot1

EMBL

AF145044 AK150692 AK150827 AY167925 AY168443 BC004647 CH466559 CR974451 U90435

GenPept

AAB58583 AAD33945 AAH04647 AAN86639 AAO39406 BAE29771 BAE29889 EDL23235

RNA Seq Atlas

14251