InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pold1

Summary

InnateDB Protein

IDBP-179127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pold1

Protein Name

polymerase (DNA directed), delta 1, catalytic subunit

Synonyms

125kDa;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039776

InnateDB Gene

IDBG-179125 (Pold1)

Protein Structure

UniProt Annotation

Function

Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0008408	3'-5' exonuclease activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000731	DNA synthesis involved in DNA repair
GO:0006139	nucleobase-containing compound metabolic process
GO:0006260	DNA replication
GO:0006287	base-excision repair, gap-filling
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0007346	regulation of mitotic cell cycle
GO:0043137	DNA replication, removal of RNA primer
GO:0045004	DNA replication proofreading
GO:0055089	fatty acid homeostasis
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0000109	nucleotide-excision repair complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016235	aggresome
GO:0043625	delta DNA polymerase complex

Protein Structure and Domains

PDB ID

MGI:97741

InterPro

IPR004578 DNA-directed DNA polymerase, family B, pol2
IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
IPR006172 DNA-directed DNA polymerase, family B
IPR012337 Ribonuclease H-like domain

PFAM

PF03104
PF00136

PRINTS

PR00106

PIRSF

SMART

SM00486

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt