Version 5.4
Mus musculus Gene: Pold1
Summary
InnateDB Gene IDBG-179125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pold1
Gene Name polymerase (DNA directed), delta 1, catalytic subunit
Synonyms 125kDa
Species Mus musculus
Ensembl Gene ENSMUSG00000038644
Encoded Proteins
IDBP-179127
polymerase (DNA directed), delta 1, catalytic subunit
IDBP-541920
polymerase (DNA directed), delta 1, catalytic subunit
IDBP-535291
polymerase (DNA directed), delta 1, catalytic subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000062822:
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3\' to 5\' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44532746-44548849
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000049343 ENSMUSP00000039776
ENSMUST00000154783
ENSMUST00000138746
ENSMUST00000136225
ENSMUST00000151793 ENSMUSP00000117157
ENSMUST00000147503
ENSMUST00000141742
ENSMUST00000123787
ENSMUST00000142483
ENSMUST00000132268
ENSMUST00000131302
ENSMUST00000145956 ENSMUSP00000117844
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000731 DNA synthesis involved in DNA repair
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006287 base-excision repair, gap-filling
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0007346 regulation of mitotic cell cycle
GO:0043137 DNA replication, removal of RNA primer
GO:0045004 DNA replication proofreading
GO:0055089 fatty acid homeostasis
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0000109 nucleotide-excision repair complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016235 aggresome
GO:0043625 delta DNA polymerase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000062822
View Gene Order
ENSBTAG00000011083
Not yet available
Pathways
NETPATH
REACTOME
REACT_262992
Processive synthesis on the lagging strand pathway
REACT_213655
Transcription-coupled NER (TC-NER) pathway
REACT_251075
Removal of the Flap Intermediate pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_202316
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_233453
Chromosome Maintenance pathway
REACT_258062
Synthesis of DNA pathway
REACT_241296
DNA strand elongation pathway
REACT_219381
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_232628
DNA Replication pathway
REACT_245705
Base Excision Repair pathway
REACT_227394
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_238177
Global Genomic NER (GG-NER) pathway
REACT_237585
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_252672
Telomere Maintenance pathway
REACT_188804
Cell Cycle pathway
REACT_188937
Metabolism pathway
REACT_235422
Nucleotide Excision Repair pathway
REACT_216529
Removal of the Flap Intermediate from the C-strand pathway
REACT_209299
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_233397
DNA Repair pathway
REACT_259967
Leading Strand Synthesis pathway
REACT_220175
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_246095
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_219337
Removal of DNA patch containing abasic residue pathway
REACT_196637
Cytosolic iron-sulfur cluster assembly pathway
REACT_236124
Mismatch Repair pathway
REACT_252545
Extension of Telomeres pathway
REACT_245471
Polymerase switching pathway
REACT_223154
Processive synthesis on the C-strand of the telomere pathway
REACT_245263
Lagging Strand Synthesis pathway
REACT_240368
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_250836
Resolution of Abasic Sites (AP sites) pathway
REACT_225604
Polymerase switching on the C-strand of the telomere pathway
REACT_253623
S Phase pathway
KEGG
mmu00240
Pyrimidine metabolism pathway
mmu03030
DNA replication pathway
mmu00230
Purine metabolism pathway
mmu03420
Nucleotide excision repair pathway
mmu03440
Homologous recombination pathway
mmu03410
Base excision repair pathway
mmu03430
Mismatch repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_7987
Polymerase switching on the C-strand of the telomere pathway
REACT_7999
Removal of the Flap Intermediate from the C-strand pathway
REACT_8027
Processive synthesis on the C-strand of the telomere pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_70
Removal of the Flap Intermediate pathway
REACT_1385
Processive synthesis on the lagging strand pathway
REACT_1792
Polymerase switching pathway
REACT_1838
Leading Strand Synthesis pathway
REACT_160176
Cytosolic iron-sulfur cluster assembly pathway
REACT_1993
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_74
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_378
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_1998
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_2192
Removal of DNA patch containing abasic residue pathway
REACT_1128
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_7970
Telomere Maintenance pathway
REACT_115566
Cell Cycle pathway
REACT_228145
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_1104
Base Excision Repair pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_228013
Mismatch Repair pathway
REACT_111217
Metabolism pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_216
DNA Repair pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa03030
DNA replication pathway
hsa00230
Purine metabolism pathway
hsa03420
Nucleotide excision repair pathway
hsa03440
Homologous recombination pathway
hsa03430
Mismatch repair pathway
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.16549
RefSeq NM_011131
OMIM
CCDS CCDS21210
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca