InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sirt6

Summary

InnateDB Protein

IDBP-179186.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sirt6

Protein Name

sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)

Synonyms

2810449N18Rik; AI043036; Sir2l6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048971

InnateDB Gene

IDBG-179184 (Sirt6)

Protein Structure

UniProt Annotation

Function

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate (By similarity). Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein. Has a role in the regulation of life span in male mice, but not in female mice. {ECO:0000250, ECO:0000269PubMed:16439206, ECO:0000269PubMed:19135889, ECO:0000269PubMed:19151729, ECO:0000269PubMed:19220062, ECO:0000269PubMed:19597350, ECO:0000269PubMed:20141841, ECO:0000269PubMed:22367546}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15795229, ECO:0000269PubMed:16439206}. Note=Predominantly nuclear. Associated with chromatin.

Disease Associations

Tissue Specificity

Highest levels are found in muscle, thymus, spleen, brain and heart (at protein level). {ECO:0000269PubMed:15795229, ECO:0000269PubMed:16439206}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017136	NAD-dependent histone deacetylase activity
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0070403	NAD+ binding

Biological Process

GO:0006471	protein ADP-ribosylation
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0016575	histone deacetylation
GO:0070932	histone H3 deacetylation