Version 5.4
Mus musculus Gene: Sirt6
Summary
InnateDB Gene IDBG-179184.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sirt6
Gene Name sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)
Synonyms 2810449N18Rik; AI043036; Sir2l6
Species Mus musculus
Ensembl Gene ENSMUSG00000034748
Encoded Proteins
IDBP-179186
sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)
IDBP-400652
sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)
IDBP-540673
sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077463:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81621785-81627797
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000042923 ENSMUSP00000048971
ENSMUST00000119324 ENSMUSP00000113953
ENSMUST00000126477
ENSMUST00000143424 ENSMUSP00000118238
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017136 NAD-dependent histone deacetylase activity
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0070403 NAD+ binding
Biological Process
GO:0006471 protein ADP-ribosylation
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0016575 histone deacetylation
GO:0070932 histone H3 deacetylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005724 nuclear telomeric heterochromatin
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000077463
View Gene Order
ENSBTAG00000019909
Not yet available
Cross-References
SwissProt P59941
TrEMBL D3YY89 Q3UKP1
UniProt Splice Variant
Entrez Gene 50721
UniGene Mm.25643
RefSeq NM_181586 NM_001163430 XM_006513862 XM_006513863
OMIM
CCDS CCDS24066 CCDS48645
HPRD
IMGT
MGI ID MGI:1354161
MGI Symbol Sirt6
EMBL AC153919 AK145929 BC052763
GenPept AAH52763 BAE26760
RNA Seq Atlas 50721

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca