InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptch2

Summary

InnateDB Protein

IDBP-179276.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptch2

Protein Name

patched homolog 2

Synonyms

ptc2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030443

InnateDB Gene

IDBG-179274 (Ptch2)

Protein Structure

UniProt Annotation

Function

May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in epithelial cells of the developing hair, tooth and whisker.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005119	smoothened binding
GO:0008158	hedgehog receptor activity

Biological Process

GO:0007165	signal transduction
GO:0008544	epidermis development
GO:0042633	hair cycle
GO:0043588	skin development

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1095405

InterPro

IPR000731 Sterol-sensing domain
IPR003392 Patched
IPR004766 Transmembrane receptor, patched

PFAM

PF02460

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35595

PhosphoSite

PhosphoSite-O35595

TrEMBL

UniProt Splice Variant

Entrez Gene

19207

UniGene

Mm.287037

RefSeq

NP_032984

MGI ID

MGI Symbol

Ptch2

OMIM

CCDS

CCDS18526

HPRD

IMGT

EMBL

AB010833 AJ133482 AJ133483 AJ133484 AJ133485 AL671866

GenPept

BAA24691 CAC88120 CAM26330