Version 5.4
Mus musculus Gene: Ptch2
Summary
InnateDB Gene IDBG-179274.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptch2
Gene Name patched homolog 2
Synonyms ptc2
Species Mus musculus
Ensembl Gene ENSMUSG00000028681
Encoded Proteins
IDBP-179276
patched homolog 2
IDBP-542865
patched homolog 2
IDBP-542866
patched homolog 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117425:
This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:117096075-117116101
Strand Forward strand
Band D1
Transcripts
ENSMUST00000030443 ENSMUSP00000030443
ENSMUST00000144620 ENSMUSP00000122548
ENSMUST00000156989
ENSMUST00000137209 ENSMUSP00000114461
ENSMUST00000135133
ENSMUST00000123226
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005119 smoothened binding
GO:0008158 hedgehog receptor activity
Biological Process
GO:0007165 signal transduction
GO:0008544 epidermis development
GO:0042633 hair cycle
GO:0043588 skin development
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117425
View Gene Order
ENSBTAG00000024137
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05217
Basal cell carcinoma pathway
mmu04340
Hedgehog signaling pathway pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_10
Hedgehog pathway
REACTOME
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04340
Hedgehog signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
hedgehog_2pathway
Signaling events mediated by the Hedgehog family
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.287037
RefSeq NM_008958
OMIM
CCDS CCDS18526
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca