InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdk1

Summary

InnateDB Protein

IDBP-179279.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdk1

Protein Name

pyruvate dehydrogenase kinase, isoenzyme 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006669

InnateDB Gene

IDBG-179277 (Pdk1)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006468	protein phosphorylation
GO:0008283	cell proliferation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906	regulation of glucose metabolic process
GO:0035556	intracellular signal transduction
GO:0097411	hypoxia-inducible factor-1alpha signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0005967	mitochondrial pyruvate dehydrogenase complex

Protein Structure and Domains

PDB ID

MGI:1926119

InterPro

IPR003594 Histidine kinase-like ATPase, ATP-binding domain
IPR005467 Signal transduction histidine kinase, core
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal

PFAM

PF02518
PF13581
PF10436

PRINTS

PIRSF

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BFP9