InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pdk1

Summary

InnateDB Gene

IDBG-179277.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdk1

Gene Name

pyruvate dehydrogenase kinase, isoenzyme 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006494

Encoded Proteins

IDBP-179279

pyruvate dehydrogenase kinase, isoenzyme 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152256:
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. [provided by RefSeq, Jul 2008]
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:71873224-71903858

Strand

Forward strand

Band

Transcripts

ENSMUST00000006669	ENSMUSP00000006669
ENSMUST00000152696
ENSMUST00000134362
ENSMUST00000156036
ENSMUST00000148249
ENSMUST00000151358
ENSMUST00000129887
ENSMUST00000129427

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006468	protein phosphorylation
GO:0008283	cell proliferation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906	regulation of glucose metabolic process
GO:0035556	intracellular signal transduction
GO:0097411	hypoxia-inducible factor-1alpha signaling pathway