InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Huwe1

Summary

InnateDB Protein

IDBP-179323.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Huwe1

Protein Name

HECT, UBA and WWE domain containing 1

Synonyms

5430439H10Rik; Arf-bp1; AU041296; C430014N20Rik; C80292; Gm1718; Ib772; LASU1; Mule; Ureb1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026292

InnateDB Gene

IDBG-179321 (Huwe1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006284	base-excision repair
GO:0006513	protein monoubiquitination
GO:0016574	histone ubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1926884

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR000569 HECT
IPR004170 WWE domain
IPR009060 UBA-like
IPR010309 E3 ubiquitin ligase, domain of unknown function DUF908
IPR010314 E3 ubiquitin ligase, domain of unknown function DUF913
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR016024 Armadillo-type fold

PFAM

PF00627
PF00632
PF02825
PF06012
PF06025

PRINTS

PIRSF

SMART

SM00119
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite