Version 5.4
Mus musculus Protein: Ablim1
Summary
InnateDB Protein IDBP-179500.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ablim1
Protein Name actin-binding LIM protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000096897
InnateDB Gene IDBG-179498 (Ablim1)
Protein Structure
UniProt Annotation
Function May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269PubMed:11163266, ECO:0000269PubMed:12849746}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:9245787}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9245787}. Note=In a striped pattern along the myofibril axis in cardiac myocytes. Associated with the cytoskeleton.
Disease Associations
Tissue Specificity Isoform 1 is detected in adult retina, where it is highly expressed in the ganglion layer. Detected in rod inner segment. Isoform 2 is highly expressed in adult retina, brain, kidney and heart. Isoform 3 is highly expressed in adult retina, brain, kidney, liver, skeletal muscle, spleen and heart. Detected in embryonic retina, brain, spinal cord, peripheral sensory ganglia and thymus. {ECO:0000269PubMed:11163266, ECO:0000269PubMed:12849746, ECO:0000269PubMed:9245787}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0007411 axon guidance
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID MGI:1194500
InterPro IPR001781 Zinc finger, LIM-type
IPR003128 Villin headpiece
PFAM PF00412
PF02209
PRINTS
PIRSF
SMART SM00132
SM00153
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K4G5
PhosphoSite PhosphoSite-Q8K4G5
TrEMBL
UniProt Splice Variant
Entrez Gene 226251
UniGene Mm.487989
RefSeq NP_001277744
MGI ID
MGI Symbol Ablim1
OMIM
CCDS CCDS70964
HPRD
IMGT
EMBL AF404774 AF404775 AF404776 AK029371 AK122196
GenPept AAM73705 AAM73706 AAM73707 BAC26424 BAC65478

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca