Version 5.4
Mus musculus Protein: Cops3
Summary
InnateDB Protein IDBP-179525.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cops3
Protein Name COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)
Synonyms Csn3; Sgn3;
Species Mus musculus
Ensembl Protein ENSMUSP00000019517
InnateDB Gene IDBG-179523 (Cops3)
Protein Structure
UniProt Annotation
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo. {ECO:0000269PubMed:12972600}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12972600}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 62 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0010388 cullin deneddylation
Cellular Component
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
Protein Structure and Domains
PDB ID MGI:1349409
InterPro IPR000717 Proteasome component (PCI) domain
PFAM PF01399
PRINTS
PIRSF
SMART SM00088
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88543
PhosphoSite PhosphoSite-O88543
TrEMBL Q3UQL2
UniProt Splice Variant
Entrez Gene 26572
UniGene Mm.40
RefSeq NP_036121
MGI ID
MGI Symbol Cops3
OMIM
CCDS CCDS24778
HPRD
IMGT
EMBL AF071313 AK142318 AK169747 BC068179
GenPept AAC33900 AAH68179 BAE25027 BAE41343

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca