Version 5.4
Mus musculus Gene: Cops3
Summary
InnateDB Gene IDBG-179523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cops3
Gene Name COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)
Synonyms Csn3; Sgn3
Species Mus musculus
Ensembl Gene ENSMUSG00000019373
Encoded Proteins
IDBP-179525
COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)
IDBP-531891
COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)
IDBP-535555
COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141030:
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:59817795-59839838
Strand Reverse strand
Band B1.3
Transcripts
ENSMUST00000019517 ENSMUSP00000019517
ENSMUST00000126489
ENSMUST00000156837 ENSMUSP00000117288
ENSMUST00000124101
ENSMUST00000136901
ENSMUST00000130027
ENSMUST00000141415 ENSMUSP00000120305
ENSMUST00000133652
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 62 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0010388 cullin deneddylation
Cellular Component
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141030
View Gene Order
ENSBTAG00000018973
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.40
RefSeq NM_011991 XM_006533381
OMIM
CCDS CCDS24778
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca