Version 5.4
| Mus musculus Protein: Nt5m | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-179586.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Nt5m | ||||||||||
| Protein Name | 5',3'-nucleotidase, mitochondrial | ||||||||||
| Synonyms | 2010013E09Rik; AI846937; dNT-2; | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Protein | ENSMUSP00000099756 | ||||||||||
| InnateDB Gene | IDBG-179584 (Nt5m) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. {ECO:0000269PubMed:12234672}. | ||||||||||
| Subcellular Localization | Mitochondrion {ECO:0000250}. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | |||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | MGI:1917127 | ||||||||||
| InterPro |
IPR010708
5\'(3\')-deoxyribonucleotidase IPR023214 HAD-like domain |
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| PFAM |
PF06941
PF00702 PF08282 PF13419 |
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| PRINTS | |||||||||||
| PIRSF | |||||||||||
| SMART | |||||||||||
| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q8VCE6 | ||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 103850 | ||||||||||
| UniGene | Mm.41761 | ||||||||||
| RefSeq | NP_598790 | ||||||||||
| MGI ID | |||||||||||
| MGI Symbol | Nt5m | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS24779 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AY061970 BC020084 BK000190 | ||||||||||
| GenPept | AAH20084 AAL35749 DAA00068 | ||||||||||