InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PI4KA

Summary

InnateDB Protein

IDBP-1796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PI4KA

Protein Name

phosphatidylinositol 4-kinase, catalytic, alpha

Synonyms

PI4K-ALPHA; pi4K230; PIK4CA;

Species

Homo sapiens

Ensembl Protein

ENSP00000255882

InnateDB Gene

IDBG-401917 (PI4KA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004428	inositol or phosphatidylinositol kinase activity
GO:0004430	1-phosphatidylinositol 4-kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0044281	small molecule metabolic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0005798	Golgi-associated vesicle
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030660	Golgi-associated vesicle membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold

PFAM

PF00454
PF00613

PRINTS

PIRSF

SMART

SM00146
SM00145

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P42356