InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppef2

Summary

InnateDB Protein

IDBP-179619.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppef2

Protein Name

protein phosphatase, EF hand calcium-binding domain 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031359

InnateDB Gene

IDBG-179617 (Ppef2)

Protein Structure

UniProt Annotation

Function

May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in retina, more specifically in photoreceptors.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005506	iron ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding
GO:0030544	Hsp70 protein binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0007601	visual perception
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0016311	dephosphorylation
GO:0043409	negative regulation of MAPK cascade
GO:0050906	detection of stimulus involved in sensory perception

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1342304

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR002048 EF-hand domain
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR012008 Serine/threonine protein phosphatase, EF-hand-containing
IPR013235 PPP domain
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00612
PF00036
PF13202
PF13405
PF00149
PF08321

PRINTS

PR00114

PIRSF

PIRSF000912

SMART

SM00015
SM00054
SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References