InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vrk3

Summary

InnateDB Protein

IDBP-179644.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vrk3

Protein Name

vaccinia related kinase 3

Synonyms

AI428238;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002275

InnateDB Gene

IDBG-179642 (Vrk3)

Protein Structure

UniProt Annotation

Function

Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. {ECO:0000269PubMed:14645249, ECO:0000269PubMed:16845380}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14645249}.

Disease Associations

Tissue Specificity

Expressed in liver, kidney, muscle, thymus, and bone marrow. Weakly expressed in spleen. {ECO:0000269PubMed:12782311}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0070373	negative regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:2182465

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt