Version 5.4
Mus musculus Gene: Vrk3
Summary
InnateDB Gene IDBG-179642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vrk3
Gene Name vaccinia related kinase 3
Synonyms AI428238
Species Mus musculus
Ensembl Gene ENSMUSG00000002205
Encoded Proteins
IDBP-179644
vaccinia related kinase 3
IDBP-532872
vaccinia related kinase 3
IDBP-627954
vaccinia related kinase 3
IDBP-532922
vaccinia related kinase 3
IDBP-627953
vaccinia related kinase 3
IDBP-627955
vaccinia related kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105053:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44748413-44777515
Strand Forward strand
Band B3
Transcripts
ENSMUST00000002275 ENSMUSP00000002275
ENSMUST00000134750
ENSMUST00000125705 ENSMUSP00000122114
ENSMUST00000147952 ENSMUSP00000130331
ENSMUST00000144515 ENSMUSP00000119073
ENSMUST00000136069
ENSMUST00000135783
ENSMUST00000171821 ENSMUSP00000132748
ENSMUST00000165957 ENSMUSP00000131704
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019903 protein phosphatase binding
Biological Process
GO:0006468 protein phosphorylation
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0070373 negative regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105053
View Gene Order
ENSBTAG00000005367
Not yet available
Cross-References
SwissProt
TrEMBL D3Z188
UniProt Splice Variant
Entrez Gene 101568
UniGene
RefSeq NM_133945 XM_006540538
OMIM
CCDS CCDS21214
HPRD
IMGT
MGI ID MGI:2182465
MGI Symbol Vrk3
EMBL AC150895 AC158231
GenPept
RNA Seq Atlas 101568

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca