InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atf5

Summary

InnateDB Protein

IDBP-179718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atf5

Protein Name

activating transcription factor 5

Synonyms

AFTA; Atf7; Atfx; ODA-10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047771

InnateDB Gene

IDBG-179716 (Atf5)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00978}.

Disease Associations

Tissue Specificity

Highest levels in liver. Expressed at low levels in heart, brain, lung, kidney, adipose tissue, and skeletal muscle. {ECO:0000269PubMed:11278933, ECO:0000269PubMed:12213205}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0031072	heat shock protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0021889	olfactory bulb interneuron differentiation
GO:0021891	olfactory bulb interneuron development
GO:0021988	olfactory lobe development
GO:0035264	multicellular organism growth
GO:0043066	negative regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048712	negative regulation of astrocyte differentiation
GO:0050768	negative regulation of neurogenesis