InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim23

Summary

InnateDB Protein

IDBP-179738.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim23

Protein Name

tripartite motif-containing 23

Synonyms

6330516O20Rik; AI450195; Arfd1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070767

InnateDB Gene

IDBG-179734 (Trim23)

Protein Structure

UniProt Annotation

Function

Acts as an E3 ubiquitin-protein ligase. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit. {ECO:0000250}.

Subcellular Localization

Endomembrane system {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Lysosome membrane {ECO:0000250}. Note=Membrane-associated with the Golgi complex and lysosomal structures. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019001	guanyl nucleotide binding
GO:0019003	GDP binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0016567	protein ubiquitination

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane

Protein Structure and Domains

PDB ID

MGI:1933161

InterPro

IPR000315 Zinc finger, B-box
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001806 Small GTPase superfamily
IPR001841 Zinc finger, RING-type
IPR003579 Small GTPase superfamily, Rab type
IPR003649 B-box, C-terminal
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR007087 Zinc finger, C2H2
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM