InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sp3

Summary

InnateDB Protein

IDBP-179758.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sp3

Protein Name

trans-acting transcription factor 3

Synonyms

D130027J01Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099750

InnateDB Gene

IDBG-179756 (Sp3)

Protein Structure

UniProt Annotation

Function

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Nucleus, PML body {ECO:0000250}. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	13 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001503	ossification
GO:0001701	in utero embryonic development
GO:0001779	natural killer cell differentiation
GO:0001829	trophectodermal cell differentiation
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030218	erythrocyte differentiation
GO:0030219	megakaryocyte differentiation
GO:0030224	monocyte differentiation
GO:0030324	lung development
GO:0030851	granulocyte differentiation
GO:0043353	enucleate erythrocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048706	embryonic skeletal system development
GO:0060136	embryonic process involved in female pregnancy
GO:0060216	definitive hemopoiesis