InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcf1

Summary

InnateDB Protein

IDBP-179788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcf1

Protein Name

ATP-binding cassette, sub-family F (GCN20), member 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036881

InnateDB Gene

IDBG-179786 (Abcf1)

Protein Structure

UniProt Annotation

Function

Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus envelope {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008494	translation activator activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0043022	ribosome binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006413	translational initiation
GO:0045727	positive regulation of translation

Cellular Component

GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0016020	membrane
GO:0042788	polysomal ribosome

Protein Structure and Domains

PDB ID

MGI:1351658

InterPro

IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR009068 S15/NS1, RNA-binding
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6P542