InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Srebf1

Summary

InnateDB Protein

IDBP-179867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srebf1

Protein Name

sterol regulatory element binding transcription factor 1

Synonyms

ADD-1; ADD1; bHLHd1; D630008H06; SREBP-1; SREBP-1a; SREBP-1c; SREBP1; SREBP1c;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020846

InnateDB Gene

IDBG-179865 (Srebf1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE- 1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC- 3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. {ECO:0000269PubMed:11782483, ECO:0000269PubMed:12855691, ECO:0000269PubMed:9329978, ECO:0000269PubMed:9784493}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:21459323}; Multi-pass membrane protein {ECO:0000269PubMed:21459323}. Golgi apparatus membrane {ECO:0000269PubMed:21459323}; Multi-pass membrane protein {ECO:0000269PubMed:21459323}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269PubMed:21459323}; Multi-pass membrane protein {ECO:0000269PubMed:21459323}. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.Processed sterol regulatory element-binding protein 1: Nucleus.

Disease Associations

Tissue Specificity

Isoform SREBP-1C predominates in liver, adrenal gland, brain and adipose tissue, whereas isoform SREBP-1A predominates in spleen. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, thymus, testis, muscle, jejunum, and ileum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	12 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0032810	sterol response element binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003062	regulation of heart rate by chemical signal
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007568	aging
GO:0007623	circadian rhythm
GO:0008203	cholesterol metabolic process
GO:0008286	insulin receptor signaling pathway
GO:0008610	lipid biosynthetic process
GO:0009267	cellular response to starvation
GO:0009749	response to glucose
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0019217	regulation of fatty acid metabolic process
GO:0030324	lung development
GO:0031065	positive regulation of histone deacetylation
GO:0032094	response to food
GO:0032526	response to retinoic acid
GO:0032570	response to progesterone
GO:0032869	cellular response to insulin stimulus
GO:0033762	response to glucagon
GO:0033993	response to lipid
GO:0042493	response to drug
GO:0043434	response to peptide hormone
GO:0045087	innate immune response (InnateDB)
GO:0045542	positive regulation of cholesterol biosynthetic process
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046676	negative regulation of insulin secretion
GO:0050796	regulation of insulin secretion
GO:0051591	response to cAMP
GO:0070542	response to fatty acid
GO:0071398	cellular response to fatty acid

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex