InnateDB Protein
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IDBP-179928.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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H1foo
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Protein Name
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H1 histone family, member O, oocyte-specific
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000036951
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InnateDB Gene
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IDBG-179926 (H1foo)
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Protein Structure
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Function |
May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling. {ECO:0000269PubMed:11171391, ECO:0000269PubMed:14729479, ECO:0000269PubMed:15371275, ECO:0000269PubMed:17519519}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus. Chromosome. Note=In the germinal vesicle oocyte, localizes to the condensed chromosomes. In the 1-cell embryo found in condensed maternal metaphase chromatin but not in the sperm head. Following second polar body extrusion, detected in the swollen sperm head as well as in the second polar body. Reduced expression in the nucleus in 2-cell embryo is seen as compared to 1-cell embryo.
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Disease Associations |
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Tissue Specificity |
Oocyte-specific. {ECO:0000269PubMed:11171391, ECO:0000269PubMed:15371275}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2176207
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InterPro |
IPR005818
Linker histone H1/H5, domain H15
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PFAM |
PF00538
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PRINTS |
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PIRSF |
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SMART |
SM00526
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VIK3
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PhosphoSite |
PhosphoSite-Q8VIK3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
171506
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UniGene |
Mm.21899
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RefSeq |
NP_612184
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MGI ID |
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MGI Symbol |
H1foo
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OMIM |
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CCDS |
CCDS20447
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HPRD |
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IMGT |
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EMBL |
AK135944
AK162137
AY007195
BC137916
CH466523
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GenPept |
AAG01890
AAI37917
BAE22736
BAE36747
EDK99547
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