Version 5.4
Mus musculus Protein: Slc6a9
Summary
InnateDB Protein IDBP-179999.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc6a9
Protein Name solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Synonyms Glyt-1; Glyt1;
Species Mus musculus
Ensembl Protein ENSMUSP00000066102
InnateDB Gene IDBG-179997 (Slc6a9)
Protein Structure
UniProt Annotation
Function Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity At E11, expressed in the ventral part of the ventricular zone. At E15, also expressed in adjacent mantle tissue and the meninges. Strongly expressed in E12 and E15 liver. {ECO:0000269PubMed:7891186, ECO:0000269PubMed:8226790}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005283 sodium:amino acid symporter activity
GO:0005328 neurotransmitter:sodium symporter activity
GO:0015187 glycine transmembrane transporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006836 neurotransmitter transport
GO:0015816 glycine transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:95760
InterPro IPR000175 Sodium:neurotransmitter symporter
IPR003028 Sodium:neurotransmitter symporter, glycine, type 1
PFAM PF00209
PRINTS PR00176
PR01204
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28571
PhosphoSite PhosphoSite-P28571
TrEMBL E9Q517
UniProt Splice Variant
Entrez Gene 14664
UniGene Mm.488958
RefSeq
MGI ID
MGI Symbol Slc6a9
OMIM
CCDS CCDS18538
HPRD
IMGT
EMBL AL627128 BC021828 X67056 X82567 X82568 X82569 X82570 X82571 X82572
GenPept AAH21828 CAA47440 CAM14713

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca