InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itm2b

Summary

InnateDB Protein

IDBP-180026.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itm2b

Protein Name

integral membrane protein 2B

Synonyms

AI256040; Bri; Bri2; Bricd2b; D14Sel6; E25BMM; imBRI2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022704

InnateDB Gene

IDBG-180024 (Itm2b)

Protein Structure

UniProt Annotation

Function

Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity). {ECO:0000250}.Mature BRI2 (mBRI2) functions as a modulator of the beta-amyloid A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed beta- amyloid protein 40 and beta-amyloid protein 42. {ECO:0000250}.Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers. {ECO:0000250}.

Subcellular Localization

Integral membrane protein 2B: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Immature BRI2 (imBRI2) is cleaved by furin in the Golgi into mBRI2 and a Bri23 peptide. mBRI2 is transported to the plasma membrane and Bri23 peptide is secreted (By similarity). {ECO:0000250}.BRI2, membrane form: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Mature BRI2 (mBRI2) needs to be transported from the endoplasmic reticulum compartment to the cell membrane in order to be able to inhibit APP processing. {ECO:0000250}.Bri23 peptide: Secreted {ECO:0000250}. Note=Detected in the cerebral spinal fluid (CSF). {ECO:0000250}.BRI2C, soluble form: Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0042985	negative regulation of amyloid precursor protein biosynthetic process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030660	Golgi-associated vesicle membrane
GO:0031301	integral component of organelle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome