InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itm2b

Summary

InnateDB Gene

IDBG-180024.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itm2b

Gene Name

integral membrane protein 2B

Synonyms

AI256040; Bri; Bri2; Bricd2b; D14Sel6; E25BMM; imBRI2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022108

Encoded Proteins

IDBP-180026

integral membrane protein 2B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136156:
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:73362231-73385271

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022704

ENSMUSP00000022704

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0042985	negative regulation of amyloid precursor protein biosynthetic process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030660	Golgi-associated vesicle membrane
GO:0031301	integral component of organelle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000136156

View Gene Order

ENSBTAG00000003109

Not yet available

Pathways

NETPATH

REACTOME

REACT_189085

Disease pathway

REACT_198563

Amyloids pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_14

IL2 pathway

REACTOME

REACT_75925

Amyloids pathway

REACT_116125

Disease pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

O89051

TrEMBL

Q9CVA8 Q9JME4

UniProt Splice Variant

Entrez Gene

16432

UniGene

Mm.405638 Mm.4266

RefSeq

NM_008410

OMIM

CCDS

CCDS27269

HPRD

IMGT

MGI ID

MGI:1309517

MGI Symbol

Itm2b

EMBL

AB030203 AB030204 AK002599 AK003587 AK005125 AK008861 AK076139 AK077482 AK150378 AK151714 AK151889 AK152068 AK152516 AK152650 AK152731 AK152983 AK153103 AK159340 AK159426 AK159619 AK159628 AK159792 AK159962 AK160725 BC004731 BC010320 BC021786 U76253

GenPept

AAC63851 AAH04731 AAH10320 AAH21786 BAA92766 BAA92767 BAB22220 BAB22877 BAB23828 BAB25935 BAC36212 BAC36822 BAE29510 BAE30633 BAE30773 BAE30922 BAE31278 BAE31387 BAE31452 BAE31632 BAE31723 BAE35002 BAE35073 BAE35235 BAE35242 BAE35374 BAE35517 BAE35970

RNA Seq Atlas

16432