InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: B4galt2

Summary

InnateDB Protein

IDBP-180090.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B4galt2

Protein Name

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2

Synonyms

Ggtb2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081352

InnateDB Gene

IDBG-180088 (B4galt2)

Protein Structure

UniProt Annotation

Function

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Trans cisternae of Golgi stack. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0003945	N-acetyllactosamine synthase activity
GO:0004461	lactose synthase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006486	protein glycosylation

Cellular Component

GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane

Protein Structure and Domains

PDB ID

MGI:1858493

InterPro

IPR003859 Beta-1,4-galactosyltransferase
IPR027791 Galactosyltransferase, C-terminal
IPR029044 Nucleotide-diphospho-sugar transferases

PFAM

PF02709

PRINTS

PR02050

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

MGI ID

MGI Symbol

OMIM

CCDS

HPRD

IMGT

EMBL

AB019541 AF142670 AK165829 AL627128 BC138567 BC138569 BC145335 CH466552

GenPept

AAF22220 AAI38568 AAI38570 AAI45336 BAA34385 BAE38399 EDL30536

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca