InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scarb2

Summary

InnateDB Protein

IDBP-180166.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scarb2

Protein Name

scavenger receptor class B, member 2

Synonyms

9330185J12Rik; Cd36l2; LGP85; LIMP-2; MLGP85;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031377

InnateDB Gene

IDBG-180164 (Scarb2)

Protein Structure

UniProt Annotation

Function

Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. {ECO:0000269PubMed:18022370, ECO:0000269PubMed:24162852}.

Subcellular Localization

Lysosome membrane {ECO:0000269PubMed:24162852, ECO:0000269PubMed:9399579}; Multi- pass membrane protein {ECO:0000269PubMed:24162852, ECO:0000269PubMed:9399579}.

Disease Associations

Tissue Specificity

Detected in the extracts of brain, heart, lung, liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0006622	protein targeting to lysosome
GO:0007155	cell adhesion

Cellular Component

GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome