InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dscam

Summary

InnateDB Protein

IDBP-180175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dscam

Protein Name

Down syndrome cell adhesion molecule

Synonyms

4932410A21Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056040

InnateDB Gene

IDBG-180173 (Dscam)

Protein Structure

UniProt Annotation

Function

Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. {ECO:0000269PubMed:18216855, ECO:0000269PubMed:18585357, ECO:0000269PubMed:19196994, ECO:0000269PubMed:19945391}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.

Disease Associations

Tissue Specificity

In the retina, expressed in dopaminergic and Nos1-positive amacrine cells and most retinal ganglion cells (at protein level). Expressed in the brain with highest levels in the cortex, olfactory bulb, hippocampus, thalamus, cerebellum and spinal cord. Expressed in the retinal ganglion layer (RGL). {ECO:0000269PubMed:11237714, ECO:0000269PubMed:11856873, ECO:0000269PubMed:18216855, ECO:0000269PubMed:19945391}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007626	locomotory behavior
GO:0042327	positive regulation of phosphorylation
GO:0048813	dendrite morphogenesis
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0060060	post-embryonic retina morphogenesis in camera-type eye
GO:0070593	dendrite self-avoidance

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030426	growth cone

Protein Structure and Domains

PDB ID

MGI:1196281

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ERC8