InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Esd

Summary

InnateDB Protein

IDBP-180330.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Esd

Protein Name

esterase D/formylglutathione hydrolase

Synonyms

Es-10; Es10; FGH; sid478;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022573

InnateDB Gene

IDBG-180328 (Esd)

Protein Structure

UniProt Annotation

Function

Serine hydrolase involved in the detoxification of formaldehyde. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasmic vesicle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008236	serine-type peptidase activity
GO:0016788	hydrolase activity, acting on ester bonds
GO:0018738	S-formylglutathione hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0046294	formaldehyde catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95421

InterPro

IPR000801 Putative esterase
IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR014186 S-formylglutathione hydrolase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00756
PF00326

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R0P3

PhosphoSite