InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mx2

Summary

InnateDB Protein

IDBP-180470.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mx2

Protein Name

myxovirus (influenza virus) resistance 2

Synonyms

AI528743; Mx-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024112

InnateDB Gene

IDBG-180468 (Mx2)

Protein Structure

UniProt Annotation

Function

Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV) and Hantaan virus (HNTV). {ECO:0000269PubMed:10233954, ECO:0000269PubMed:11266216}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10233954}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	0
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0009615	response to virus
GO:0034340	response to type I interferon
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response
GO:0051607	defense response to virus

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:97244

InterPro

IPR000375 Dynamin central domain
IPR001401 Dynamin, GTPase domain
IPR003130 Dynamin GTPase effector
IPR022812 Dynamin superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01031
PF00350
PF02212

PRINTS

PR00195

PIRSF

SMART

SM00053
SM00302

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt