Version 5.4
| Mus musculus Protein: Pnlip | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-180519.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Pnlip | ||||||||
| Protein Name | pancreatic lipase | ||||||||
| Synonyms | 1810007A24Rik; PL; PTL; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000056377 | ||||||||
| InnateDB Gene | IDBG-180517 (Pnlip) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Pancreas. {ECO:0000269PubMed:10769148}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:97722 | ||||||||
| InterPro |
IPR000734
Lipase IPR001024 PLAT/LH2 domain IPR002331 Pancreatic lipase IPR008976 Lipase/lipooxygenase, PLAT/LH2 IPR013818 Lipase, N-terminal IPR016272 Lipoprotein lipase, LIPH IPR029058 Alpha/Beta hydrolase fold |
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| PFAM |
PF01477
PF00151 |
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| PRINTS |
PR00821
PR00823 |
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| PIRSF |
PIRSF000865
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| SMART |
SM00308
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q6P8U6 | ||||||||
| PhosphoSite | PhosphoSite-Q6P8U6 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 69060 | ||||||||
| UniGene | Mm.20407 | ||||||||
| RefSeq | NP_081201 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Pnlip | ||||||||
| OMIM | |||||||||
| CCDS | CCDS29930 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AY387690 BC061061 CH466585 | ||||||||
| GenPept | AAH61061 AAQ90020 EDL01803 | ||||||||