InnateDB Protein
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IDBP-18052.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SEC13
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Protein Name
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SEC13 homolog (S. cerevisiae)
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Synonyms
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D3S1231E; npp-20; SEC13L1; SEC13R;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000336566
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InnateDB Gene
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IDBG-18046 (SEC13)
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Protein Structure
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Function |
Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway. {ECO:0000269PubMed:23723238, ECO:0000269PubMed:8972206}.
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Subcellular Localization |
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=In interphase, localizes at both sides of the NPC.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
38
[view]
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Protein-Protein |
38
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
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PFAM |
PF00400
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
P55735
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PhosphoSite |
PhosphoSite-P55735
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TrEMBL |
E7ERC8
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UniProt Splice Variant |
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Entrez Gene |
6396
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UniGene |
Hs.166924
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RefSeq |
NP_109598
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HUGO |
HGNC:10697
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OMIM |
600152
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CCDS |
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HPRD |
02538
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IMGT |
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EMBL |
AC022384
AF052155
AK301999
BC002634
BC006167
BC091506
EF036494
L09260
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GenPept |
AAH02634
AAH06167
AAH91506
ABO65080
BAG63403
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