Version 5.4
Homo sapiens Gene: SEC13
Summary
InnateDB Gene IDBG-18046.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC13
Gene Name SEC13 homolog (S. cerevisiae)
Synonyms D3S1231E; npp-20; SEC13L1; SEC13R
Species Homo sapiens
Ensembl Gene ENSG00000157020
Encoded Proteins
IDBP-18048
SEC13 homolog (S. cerevisiae)
IDBP-18052
SEC13 homolog (S. cerevisiae)
IDBP-18054
SEC13 homolog (S. cerevisiae)
IDBP-236077
SEC13 homolog (S. cerevisiae)
IDBP-236079
SEC13 homolog (S. cerevisiae)
IDBP-363042
SEC13 homolog (S. cerevisiae)
IDBP-363049
SEC13 homolog (S. cerevisiae)
IDBP-363052
SEC13 homolog (S. cerevisiae)
IDBP-363055
SEC13 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:10293131-10321178
Strand Reverse strand
Band p25.3
Transcripts
ENST00000383801 ENSP00000373312
ENST00000337354 ENSP00000336566
ENST00000350697 ENSP00000312122
ENST00000397117 ENSP00000380306
ENST00000397109 ENSP00000380298
ENST00000397105
ENST00000397102
ENST00000397101
ENST00000397099
ENST00000431352 ENSP00000401368
ENST00000428626 ENSP00000400260
ENST00000445064 ENSP00000398623
ENST00000432213 ENSP00000404141
ENST00000492602
ENST00000479868
ENST00000477547
ENST00000476597
ENST00000490283
ENST00000482647
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006886 intracellular protein transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048208 COPII vesicle coating
GO:0051028 mRNA transport
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0000776 kinetochore
GO:0005635 nuclear envelope
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0012507 ER to Golgi transport vesicle membrane
GO:0031080 nuclear pore outer ring
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030298
View Gene Order
ENSBTAG00000017825
Not yet available
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_75795
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_12507
COPII (Coat Protein 2) Mediated Vesicle Transport pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_11203
ER to Golgi Transport pathway
REACT_115566
Cell Cycle pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_11123
Membrane Trafficking pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa03013
RNA transport pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.166924
RefSeq NM_001136026 NM_001136232 NM_030673 NM_183352 XM_005265378 XM_005265379 XM_006713286 XM_006713287 XM_006713288
HUGO
OMIM
CCDS CCDS2599 CCDS46751 CCDS63540
HPRD 02538
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca