InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEC13

Summary

InnateDB Protein

IDBP-18054.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC13

Protein Name

SEC13 homolog (S. cerevisiae)

Synonyms

D3S1231E; npp-20; SEC13L1; SEC13R;

Species

Homo sapiens

Ensembl Protein

ENSP00000312122

InnateDB Gene

IDBG-18046 (SEC13)

Protein Structure

UniProt Annotation

Function

Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway. {ECO:0000269PubMed:23723238, ECO:0000269PubMed:8972206}.

Subcellular Localization

Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=In interphase, localizes at both sides of the NPC.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0048208	COPII vesicle coating
GO:0051028	mRNA transport
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0000776	kinetochore
GO:0005635	nuclear envelope
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0012507	ER to Golgi transport vesicle membrane
GO:0031080	nuclear pore outer ring
GO:0070062	extracellular vesicular exosome