InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alox5

Summary

InnateDB Protein

IDBP-180620.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alox5

Protein Name

arachidonate 5-lipoxygenase

Synonyms

5-LO; 5-LOX; 5LO; 5LX; AI850497; F730011J02;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026795

InnateDB Gene

IDBG-180618 (Alox5)

Protein Structure

UniProt Annotation

Function

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. {ECO:0000269PubMed:7629107}.

Subcellular Localization

Cytoplasm {ECO:0000255PROSITE- ProRule:PRU00726, ECO:0000269PubMed:7629107}. Nucleus matrix {ECO:0000269PubMed:7629107}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004051	arachidonate 5-lipoxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872	metal ion binding

Biological Process

GO:0002540	leukotriene production involved in inflammatory response
GO:0006691	leukotriene metabolic process
GO:0006954	inflammatory response
GO:0019370	leukotriene biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005641	nuclear envelope lumen
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016363	nuclear matrix
GO:0031965	nuclear membrane