InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Alox5

Summary

InnateDB Gene

IDBG-180618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alox5

Gene Name

arachidonate 5-lipoxygenase

Synonyms

5-LO; 5-LOX; 5LO; 5LX; AI850497; F730011J02

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025701

Encoded Proteins

IDBP-180620

arachidonate 5-lipoxygenase

IDBP-627126

arachidonate 5-lipoxygenase

IDBP-627127

arachidonate 5-lipoxygenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000012779:
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:116410077-116461178

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026795	ENSMUSP00000026795
ENSMUST00000167447
ENSMUST00000169625
ENSMUST00000164547	ENSMUSP00000130780
ENSMUST00000170186	ENSMUSP00000130424
ENSMUST00000167585
ENSMUST00000167174

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004051	arachidonate 5-lipoxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872	metal ion binding

Biological Process

GO:0002540	leukotriene production involved in inflammatory response
GO:0006691	leukotriene metabolic process
GO:0006954	inflammatory response
GO:0019370	leukotriene biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005641	nuclear envelope lumen
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016363	nuclear matrix
GO:0031965	nuclear membrane