Version 5.4
Mus musculus Protein: Ramp1
Summary
InnateDB Protein IDBP-180652.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ramp1
Protein Name receptor (calcitonin) activity modifying protein 1
Synonyms 9130218E19Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000095253
InnateDB Gene IDBG-180648 (Ramp1)
Protein Structure
UniProt Annotation
Function Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. {ECO:0000269PubMed:10854696, ECO:0000269PubMed:12147211}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed predominantly in the thymus, skeletal muscle, embryonic and adult brain, embryonic and adult lung, and colon. {ECO:0000269PubMed:10777702, ECO:0000269PubMed:10854696, ECO:0000269PubMed:12147211}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004948 calcitonin receptor activity
GO:0005515 protein binding
GO:0008565 protein transporter activity
GO:0015026 coreceptor activity
GO:0031716 calcitonin receptor binding
Biological Process
GO:0001525 angiogenesis
GO:0006816 calcium ion transport
GO:0006886 intracellular protein transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0015031 protein transport
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031623 receptor internalization
GO:0060050 positive regulation of protein glycosylation
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID MGI:1858418
InterPro IPR006985 Receptor activity modifying protein
PFAM PF04901
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WTJ5
PhosphoSite PhosphoSite-Q9WTJ5
TrEMBL Q9CT60
UniProt Splice Variant
Entrez Gene 51801
UniGene Mm.3272
RefSeq NP_058590
MGI ID
MGI Symbol Ramp1
OMIM
CCDS CCDS15158
HPRD
IMGT
EMBL AB019046 AF146522 AF209904 AJ250489 AK004539 AK157896 AK165238 BC012644 CH466520
GenPept AAD35018 AAF21036 AAH12644 BAA76617 BAB23355 BAE34250 BAE38095 CAB59511 EDL40060

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca