InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ramp1

Summary

InnateDB Gene

IDBG-180648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ramp1

Gene Name

receptor (calcitonin) activity modifying protein 1

Synonyms

9130218E19Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034353

Encoded Proteins

IDBP-180652

receptor (calcitonin) activity modifying protein 1

IDBP-628260

receptor (calcitonin) activity modifying protein 1

IDBP-788644

receptor (calcitonin) activity modifying protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132329:
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:91179822-91225196

Strand

Forward strand

Band

Transcripts

ENSMUST00000097648	ENSMUSP00000095253
ENSMUST00000165855	ENSMUSP00000128679
ENSMUST00000188475	ENSMUSP00000139720

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004948	calcitonin receptor activity
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0015026	coreceptor activity
GO:0031716	calcitonin receptor binding

Biological Process

GO:0001525	angiogenesis
GO:0006816	calcium ion transport
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0015031	protein transport
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031623	receptor internalization
GO:0060050	positive regulation of protein glycosylation
GO:0072659	protein localization to plasma membrane